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Nat Commun 15, 8498 (2024)

Stop or switch in consultation with your prescriber if any of the following appear despite hitting the 7 rules above: hand-grip strength drops more than 10% from baseline, you cannot climb one flight of stairs without significant fatigue, a 6-month DEXA shows more than 25% of total weight loss as lean mass, or you are losing more than 1.5% of bodyweight per week despite eating 1.6 g of protein per kilogram

Jardiance is associated more with infection-related risks and dehydration, while Ozempic is linked to gastrointestinal side effects and specific warnings regarding thyroid tumors

References: Enteroendocrine L Cells Sense LPS After Gut Barrier Injury to Enhance GLP-1 Secretion